Journal article
Reduction of blood group A antigen on erythrocytes in a patient with myelodysplastic syndrome harboring somatic mutations in RUNX1 and GATA2
Abstract
BACKGROUND: Reduction of blood group ABO antigens on red blood cells (RBCs) is well known in patients with leukemias, and this reduction of ABO expression is strongly associated with DNA methylation of the ABO promoter. Previously, we reported a two-nucleotide deletion in RUNX1 encoding an abnormally elongated protein lacking the trans-activation domain in a patient with myelodysplastic syndrome (MDS) showing A-antigen loss on RBCs. This …
Authors
Hayakawa A; Sano R; Takahashi Y; Okawa T; Kubo R; Harada M; Fukuda H; Yokohama A; Handa H; Kawabata‐Iwakawa R
Journal
Transfusion, Vol. 62, No. 2, pp. 469–480
Publisher
Wiley
Publication Date
February 2022
DOI
10.1111/trf.16766
ISSN
0041-1132