Carpal tunnel tendon and sub-synovial connective tissue mechanics are affected by reduced venous return

BACKGROUND: The effects of blood flow occlusion and sex-specific differences in tendon-subsynovial connective tissue relative strain are not well understood. Thus, the purpose of this study was to investigate the influence of blood flow, biological sex, and finger movement speed on carpal tunnel tendon mechanics to further develop our understanding of carpal tunnel syndrome. METHODS: Colour Doppler ultrasound imaging quantified relative motion between flexor digitorum superficialis tendon and subsynovial connective tissue in 20 healthy male and female participants during repetitive finger flexion-extension under brachial occlusion of blood flow and two movement speeds (0.75 & 1.25 Hz). FINDINGS: Flexor digitorum superficialis and subsynovial connective tissue displacement decreased with occlusion (small effect) and fast speed (large effect). Speed × Condition interactions were found for mean FDS displacement and peak FDS velocity, where slow speed with occlusion reduced both outcomes. Movement speed had a small but significant effect on tendon-subsynovial connective tissue shear outcomes, where MVR decreased with fast finger motion. INTERPRETATION: These results suggest the influence of localized edema through venous occlusion on tendon-subsynovial connective tissue gliding within the carpal tunnel. This insight further develops our understanding of carpal tunnel syndrome pathophysiology and suggests ramifications on carpal tunnel tissue motion when the local fluid environment of the carpal tunnel is disturbed.