SAT0565 Adjusting for the intra-articular placebo effect in knee osteoarthritis therapies

Background Currently, there is a large debate regarding the appropriateness of intra-articular (IA)-saline injection as a “placebo” comparator in knee osteoarthritis (OA) trials and meta-analyses. There is substantial evidence to suggest that the injection of saline into the joint is not without treatment effect. Objectives This study aimed to assess the current literature's estimates of the IA-saline treatment effect against a range of …