Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder Journal Articles uri icon

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abstract

  • Abstract Background Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample. Methods Data for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P ≤ 0.001. Results The 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger. Conclusion UVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition.

authors

  • Bauer, Michael
  • Glenn, Tasha
  • Achtyes, Eric D
  • Alda, Martin
  • Agaoglu, Esen
  • Altınbaş, Kürsat
  • Andreassen, Ole A
  • Angelopoulos, Elias
  • Ardau, Raffaella
  • Aydin, Memduha
  • Ayhan, Yavuz
  • Baethge, Christopher
  • Bauer, Rita
  • Baune, Bernhard T
  • Balaban, Ceylan
  • Becerra-Palars, Claudia
  • Behere, Aniruddh P
  • Behere, Prakash B
  • Belete, Habte
  • Belete, Tilahun
  • Belizario, Gabriel Okawa
  • Bellivier, Frank
  • Belmaker, Robert H
  • Benedetti, Francesco
  • Berk, Michael
  • Bersudsky, Yuly
  • Bicakci, Şule
  • Birabwa-Oketcho, Harriet
  • Bjella, Thomas D
  • Brady, Conan
  • Cabrera, Jorge
  • Cappucciati, Marco
  • Castro, Angela Marianne Paredes
  • Chen, Wei-Ling
  • Cheung, Eric YW
  • Chiesa, Silvia
  • Crowe, Marie
  • Cuomo, Alessandro
  • Dallaspezia, Sara
  • Del Zompo, Maria
  • Desai, Pratikkumar
  • Dodd, Seetal
  • Etain, Bruno
  • Fagiolini, Andrea
  • Fellendorf, Frederike T
  • Ferensztajn-Rochowiak, Ewa
  • Fiedorowicz, Jess G
  • Fountoulakis, Kostas N
  • Frye, Mark A
  • Geoffroy, Pierre A
  • Gitlin, Michael J
  • Gonzalez-Pinto, Ana
  • Gottlieb, John F
  • Grof, Paul
  • Haarman, Bartholomeus CM
  • Harima, Hirohiko
  • Hasse-Sousa, Mathias
  • Henry, Chantal
  • Hoffding, Lone
  • Houenou, Josselin
  • Imbesi, Massimiliano
  • Isometsä, Erkki T
  • Ivkovic, Maja
  • Janno, Sven
  • Johnsen, Simon
  • Kapczinski, Flavio
  • Karakatsoulis, Gregory N
  • Kardell, Mathias
  • Kessing, Lars Vedel
  • Kim, Seong Jae
  • König, Barbara
  • Kot, Timur L
  • Koval, Michael
  • Kunz, Mauricio
  • Lafer, Beny
  • Landén, Mikael
  • Larsen, Erik R
  • Lenger, Melanie
  • Licht, Rasmus W
  • Lopez-Jaramillo, Carlos
  • MacKenzie, Alan
  • Madsen, Helle Østergaard
  • Madsen, Simone Alberte Kongstad A
  • Mahadevan, Jayant
  • Mahardika, Agustine
  • Manchia, Mirko
  • Marsh, Wendy
  • Martinez-Cengotitabengoa, Monica
  • Martini, Julia
  • Martiny, Klaus
  • Mashima, Yuki
  • McLoughlin, Declan M
  • Meesters, Ybe
  • Melle, Ingrid
  • Meza-Urzúa, Fátima
  • Mikolas, Pavol
  • Mok, Yee Ming
  • Monteith, Scott
  • Moorthy, Muthukumaran
  • Morken, Gunnar
  • Mosca, Enrica
  • Mozzhegorov, Anton A
  • Munoz, Rodrigo
  • Mythri, Starlin V
  • Nacef, Fethi
  • Nadella, Ravi K
  • Nakanotani, Takako
  • Nielsen, René Ernst
  • O’Donovan, Claire
  • Omrani, Adel
  • Osher, Yamima
  • Ouali, Uta
  • Pantovic-Stefanovic, Maja
  • Pariwatcharakul, Pornjira
  • Petite, Joanne
  • Petzold, Johannes
  • Pfennig, Andrea
  • Ruiz, Yolanda Pica
  • Pinna, Marco
  • Pompili, Maurizio
  • Porter, Richard J
  • Quiroz, Danilo
  • Rabelo-da-Ponte, Francisco Diego
  • Ramesar, Raj
  • Rasgon, Natalie
  • Ratta-apha, Woraphat
  • Ratzenhofer, Michaela
  • Redahan, Maria
  • Reddy, MS
  • Reif, Andreas
  • Reininghaus, Eva Z
  • Richards, Jenny Gringer
  • Ritter, Philipp
  • Rybakowski, Janusz K
  • Sathyaputri, Leela
  • Scippa, Angela M
  • Simhandl, Christian
  • Smith, Daniel
  • Smith, José
  • Stackhouse, Paul W
  • Stein, Dan J
  • Stilwell, Kellen
  • Strejilevich, Sergio
  • Su, Kuan-Pin
  • Subramaniam, Mythily
  • Sulaiman, Ahmad Hatim
  • Suominen, Kirsi
  • Tanra, Andi J
  • Tatebayashi, Yoshitaka
  • Teh, Wen Lin
  • Tondo, Leonardo
  • Torrent, Carla
  • Tuinstra, Daniel
  • Uchida, Takahito
  • Vaaler, Arne E
  • Vieta, Eduard
  • Viswanath, Biju
  • Yoldi-Negrete, Maria
  • Yalcinkaya, Oguz Kaan
  • Young, Allan H
  • Zgueb, Yosra
  • Whybrow, Peter C

publication date

  • June 22, 2023