Abstract 6028: Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma

Abstract [Background] Medulloblastoma (MB) is the most frequently diagnosed malignant pediatric brain tumor. Multiple integrated genomic analyses have been used to stratify MB into four molecular subgroups, each unique in its gene expression profile, clinical characteristics, and prognosis. MYC-driven group 3 MB (G3MB) tumors are poorly understood entities, defined by metastasis down the leptomeninges, disease recurrence and …