Neonatal and Early Childhood Outcomes of Twin and Singleton Infants Born Preterm Journal Articles uri icon

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abstract

  • OBJECTIVE: To compare neonatal and early-childhood outcomes of twins and singletons born preterm and explore the association of chorionicity with outcomes. STUDY DESIGN: This was a national retrospective cohort study of singleton and twin infants admitted at 230/7-286/7 weeks to level III neonatal intensive care units in Canada (2010-2020). The primary neonatal outcome was a composite of neonatal death or severe neonatal morbidities. The primary early-childhood outcome was a composite of death or significant neurodevelopmental impairment. RESULTS: The study cohort included 3554 twin and 12 815 singleton infants. Twin infants born at 230/7-256/7 weeks had a greater risk of the composite neonatal outcome (adjusted risk ratio 1.04, 95% CI 1.01-1.07). However, these differences were limited to the subgroups of same-sex and monochorionic twin pregnancies. Twin infants of 230/7-256/7 weeks were also at an increased risk of the composite early-childhood outcome (adjusted risk ratio 1.22, 95% CI 1.09-1.37). Twin infants of 260/7-286/7 weeks were not at an increased risk of adverse neonatal outcomes or the composite early-childhood outcome compared with singleton infants. CONCLUSIONS: Among infants born at 230/7-256/7 weeks, twins have a greater risk of adverse neonatal outcomes and the composite early-childhood outcome than singleton infants. However, the increased risk of adverse neonatal outcomes is mostly limited to monochorionic twins and may thus be driven by complications related to monochorionic placentation.

authors

  • Melamed, Nir
  • Weitzner, Omer
  • Church, Paige
  • Banihani, Rudaina
  • Barrett, Jon
  • Yang, Junmin
  • Wong, Jonathan
  • Piedboeuf, Bruno
  • Shah, Prakesh S
  • Shah, Prakesh S
  • Beltempo, Marc
  • Kanungo, Jaideep
  • Wong, Jonathan
  • Stavel, Miroslav
  • Sherlock, Rebecca
  • Mehrem, Ayman Abou
  • Toye, Jennifer
  • Ting, Joseph
  • Fajardo, Carlos
  • Bodani, Jaya
  • Strueby, Lannae
  • Seshia, Mary
  • Louis, Deepak
  • Alvaro, Ruben
  • Mukerji, Amit
  • Da Silva, Orlando
  • Augustine, Sajit
  • Lee, Kyong-Soon
  • Ng, Eu-gene
  • Lemyre, Brigitte
  • Daboval, Thierry
  • Khurshid, Faiza
  • Bizgu, Victoria
  • Barrington, Keith
  • Lapointe, Anie
  • Ethier, Guillaume
  • Drolet, Christine
  • Piedboeuf, Bruno
  • Claveau, Martine
  • St-Hilaire, Marie
  • Bertelle, Valerie
  • Masse, Edith
  • Mehdizadeh-Hakak, Hamid
  • Makary, Hala
  • Ojah, Cecil
  • Hudson, Jo-Anna
  • Afifi, Jehier
  • Aslam, Ameer
  • Lee, Shoo K
  • Abenhaim, Haim
  • Afifi, Jehier
  • Alvaro, Ruben
  • Andrews, James
  • Armson, Anthony
  • Audibert, Francois
  • Aziz, Khalid
  • Ballantyne, Marilyn
  • Barrett, Jon
  • Beltempo, Marc
  • Berard, Anick
  • Bertelle, Valerie
  • Blais, Lucie
  • Bocking, Alan
  • Bodani, Jaya
  • Burrows, Jason
  • Butt, Kimberly
  • Canning, Roderick
  • Carson, George
  • Chaillet, Nils
  • Chandra, Sue
  • Church, Paige
  • Cieslak, Zenon
  • Coughlin, Kevin
  • Crane, Joan
  • Creighton, Dianne
  • Da Silva, Orlando
  • Daboval, Thierry
  • Dahlgren, Leanne
  • Daspal, Sibasis
  • de Cabo, Cecilia
  • Deshpandey, Akhil
  • Dow, Kimberly
  • Drolet, Christine
  • Dunn, Michael
  • Helou, Salhab el
  • El-Chaar, Darine
  • El-Naggar, Walid
  • Fajardo, Carlos
  • Foster, Jonathan
  • Gagnon, Robert
  • Gratton, Rob
  • Han, Victor
  • Harrison, Adele
  • Hasan, Shabih
  • Helewa, Michael
  • Hicks, Matthew
  • Joseph, KS
  • Kajetanowicz, Andrzej
  • Kalapesi, Zarin
  • Khairy, May
  • Lacaze-Masmonteil, Thierry
  • Lee, Kyong-Soon
  • Lemyre, Brigitte
  • Lodha, Abhay
  • Louis, Deepak
  • Luu, Thuy Mai
  • Ly, Linh
  • Majnemer, Annette
  • Makary, Hala
  • Marc, Isabelle
  • Masse, Edith
  • McDonald, Sarah
  • McMillan, Doug
  • Melamed, Nir
  • Metcalfe, Amy
  • Moddemann, Diane
  • Monterrosa, Luis
  • Morais, Michelle
  • Mukerji, Amit
  • Mundle, William
  • Murphy, Lynn
  • Murphy, Kellie
  • Nuyt, Anne-Monique
  • Nwaesei, Chuks
  • O'Brien, Karel
  • Offringa, Martin
  • Ojah, Cecil
  • Ouellet, Annie
  • Pasquier, Jean-Charles
  • Pechlivanoglou, Petros
  • Pelausa, Ermelinda
  • Piedboeuf, Bruno
  • Portales-Casamar, Elodie
  • Premji, Shahirose
  • Puligandla, Pramod
  • Pullenayegum, Eleanor
  • Reichert, Amber
  • Robson, Kate
  • Schneider, Carol
  • Seshia, Mary
  • Shah, Prakesh S
  • Shah, Vibhuti
  • Sherlock, Rebecca
  • Shivananda, Sandesh
  • Singhal, Nalini
  • Skarsgard, Erik
  • Skoll, Amanda
  • Smith, Graeme
  • Synnes, Anne
  • Thériault, Katherine
  • Ting, Joseph
  • Tough, Suzanne
  • Toye, Jennifer
  • Ubhi, Jagdeep
  • Vincer, Michael
  • Whittle, Wendy
  • Whyte, Hilary
  • Wilson, Doug
  • Wood, Stephen
  • Ye, Philip
  • Yee, Wendy
  • Zwicker, Jill
  • Pillay, Thevanisha
  • Synnes’, Anne
  • Colby, Lindsay
  • Zwicker, Jill
  • Anson, Shelagh
  • Sherlock, Rebecca
  • Stavel, Miroslav
  • Moodley, Anitha
  • Hendson, Leonora
  • Reichert, Amber
  • Hicks, Matthew
  • Moddemann, Diane
  • de Cabo, Cecilia
  • Ricci, M Florencia
  • Augustine, Sajit
  • McKnight, Sarah
  • Coughlin, Kevin
  • Ly, Linh
  • Kelly, Edmond
  • Raghuram, Kamini
  • Thomas, Karen
  • Church, Paige
  • Banihani, Rudaina
  • Nguyen, Kim-Anh
  • Mandel, Ruth
  • Khairy, May
  • Beltempo, Marc
  • Luu, Thuy Mai
  • Morin, Alyssa
  • Bélanger, Sylvie
  • Afifi, Jehier

publication date

  • November 2023