Preprint
Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications
Abstract
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes. To characterise the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study (GWAS) data from 2,535,601 individuals (39.7% non-European ancestry), including 428,452 T2D cases. We identify 1,289 independent association signals at genome-wide significance (P<5×10-8) that map to 611 loci, of …
Authors
Suzuki K; Hatzikotoulas K; Southam L; Taylor HJ; Yin X; Lorenz KM; Mandla R; Huerta-Chagoya A; Rayner NW; Bocher O
DOI
10.1101/2023.03.31.23287839
Preprint server
medRxiv