Journal article
Skin regeneration is accelerated by a lower dose of multipotent mesenchymal stromal/stem cells—a paradigm change
Abstract
BackgroundMultipotent mesenchymal stromal/stem cell (MSC) therapy is under investigation in promising (pre-)clinical trials for wound healing, which is crucial for survival; however, the optimal cell dosage remains unknown. The aim was to investigate the efficacy of different low-to-high MSC dosages incorporated in a biodegradable collagen-based dermal regeneration template (DRT) Integra®.MethodsWe conducted a porcine study (N = 8 Yorkshire …
Authors
Eylert G; Dolp R; Parousis A; Cheng R; Auger C; Holter M; Lang-Olip I; Reiner V; Kamolz L-P; Jeschke MG
Journal
Stem Cell Research & Therapy, Vol. 12, No. 1,
Publisher
Springer Nature
DOI
10.1186/s13287-020-02131-6
ISSN
1757-6512