Synthesis and Evaluation of Fluorous-Tagged and Polystyrene-Supported Precursors for Fluoro-benziodoxole

Abstract Fluoro-benziodoxole, a fluorinated hypervalent iodine (HVI) reagent, has been prepared by fluoride exchange with fluorous- or polystyrene-based sulfonyloxy-benziodoxole precursors. Key to this strategy was the facile O-sulfonylation of a common hydroxy-benziodoxole precursor with sulfonyl chlorides, which enabled the easy synthesis and evaluation of previously unknown fluorous- or polystyrene-based fluoride exchange precursors. …