Purine nucleosides protect injured neurons and stimulate neuronal regeneration by intracellular and membrane receptor‐mediated mechanisms

Abstract Like adenine‐based purines, extracellular nonadenine‐based purines have a multitude of trophic effects on the growth, differentiation, and survival of target cells. The nonadenine‐based purines, which include guanosine, inosine, and GTP, apparently exert their trophic effects by interacting with both intercellular targets as well as those on the cell surface. Specifically, guanosine and inosine target the protein kinase N‐kinase, in …