P10 The Effect Of Naltrexone, An Opioid Receptor Antagonist, On Capsaicin Evoked Cough, In Healthy Male Subjects

Introduction Chronic cough is a troublesome condition that reduces patient quality of life. Recent evidence suggests that healthy females cough more than healthy males but the mechanism underlying this in unclear.1 We hypothesise that opiate-sensitive inhibitory control mechanisms determine capsaicin-evoked cough responses in healthy subjects. Aim To show that in healthy males the number of capsaicin-evoked coughs is increased following …