P10 The Effect Of Naltrexone, An Opioid Receptor Antagonist, On Capsaicin Evoked Cough, In Healthy Male Subjects

Introduction Chronic cough is a troublesome condition that reduces patient quality of life. Recent evidence suggests that healthy females cough more than healthy males but the mechanism underlying this in unclear.1 We hypothesise that opiate-sensitive inhibitory control mechanisms determine capsaicin-evoked cough responses in healthy subjects. Aim To show that in healthy males the number of capsaicin-evoked coughs is increased following administration of naltrexone, an opiate receptor antagonist, compared with placebo. Method 15 male subjects (median age 30 yrs (21–59)) were recruited in to a randomised double blind cross-over trial of single doses of naltrexone vs. placebo given 1 week apart. A capsaicin inhalational challenge (doubling doses 0.48 to 125[micro]M) was performed 60 min after ingestion of naltrexone/placebo using a dosimeter. Four inhalations 30 seconds apart were performed at each concentration and the total coughs evoked at each dose were recorded and verified using a cough monitor.