Journal article
Effects of a novel sodium channel blocker, GSK2339345, in patients with refractory chronic cough.
Abstract
OBJECTIVE: Voltage-gated sodium channels (VGSC) are important in the initiation and propagation of action potentials in afferent sensory nerve fibers responsible for evoking cough. This study investigated the efficacy of GSK2339345, a VGSC inhibitor, in the treatment of refractory chronic cough (RCC).
METHODS: A three-part randomized, double-blind, placebo-controlled, cross-over study was conducted in the UK. In part A, patients with RCC …
Authors
Smith JA; McGarvey LPA; Badri H; Satia I; Warren F; Siederer S; Liefaard L; Murdoch RD; Povey K; Marks-Konczalik J
Journal
International Journal of Clinical Pharmacology and Therapeutics, Vol. 55, No. 9, pp. 712–719
Publisher
Dustri-Verlag Dr. Karl Feistle
Publication Date
July 6, 2017
DOI
10.5414/cp202804
ISSN
0946-1965