CORM‐3‐derived CO attenuates oxidative stress in vascular endothelial cells in SOD‐activity independent manner

Our previous studies indicate that CO derived from CO‐releasing molecule, CORM‐3, while suppressing PMN transendothelial migration at the same time amplifies oxidative stress in PMN, whereas oxidative stress in vascular endothelial cells (HUVEC) is effectively suppressed by CORM‐3. However, the mechanisms of such opposing effects of CO with respect to ROS production are unknown. In this study we assessed the effects of CORM‐3‐derived CO on …