Solid-phase Suzuki cross-coupling reactions using a phosphine ligand based on a phospha-adamantane framework

The use of a catalyst system based on Pd2dba3·CHCl3 and 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phenyl-6-phospha-adamantane allows for Suzuki coupling aryl halides with an array of boronic acids on a solid-phase platform. The reactions can be carried out at room temperature with low palladium loadings in high yields.