Carborane-carbohydrate derivatives Versatile platforms for developing targeted radiopharmaceuticals

A series of carborane-carbohydrate derivatives were prepared as model platforms for developing targeted radiopharmaceuticals in which a single ligand can be tagged with two different classes of radionuclides. A nido-carborane linked to glucose was synthesized and the cage labelled with a radiometal ( 99m Tc) and a radiohalogen ( 125 I) in good radiochemical yield. The 99m Tc-metallocarborane derivative was prepared via microwave-assisted …