The total synthesis of a technetium chelate - tamoxifen complex Journal Articles

abstract

• A potential agent for imaging breast cancer has been synthesized by derivatization of the anti-estrogen tamoxifen. A multistep synthesis was required to conjugate a technetium chelate to tamoxifen in such a fashion that the biodistribution of the complex should mimic that of the parent compound.Key words: tamoxifen, radioimaging, technetium, synthesis.

authors

• Bell, Russell A
• Dickson, Kieran C
• Valliant, John F

status

• published 

publication date

• January 1, 1999

has subject area

• 03 Chemical Sciences (FoR)
• General Chemistry (Science Metrix)

published in

• Canadian Journal of Chemistry  Journal

keywords

• BREAST
• Chemistry
• Chemistry, Multidisciplinary
• DERIVATIVES
• Physical Sciences
• Science & Technology
• radioimaging
• synthesis
• tamoxifen
• technetium

Digital Object Identifier (DOI)

• 10.1139/v98-220

start page

• 146

end page

• 154

volume

• 77

issue

• 1