Journal article
The total synthesis of a technetium chelate - tamoxifen complex
Abstract
A potential agent for imaging breast cancer has been synthesized by derivatization of the anti-estrogen tamoxifen. A multistep synthesis was required to conjugate a technetium chelate to tamoxifen in such a fashion that the biodistribution of the complex should mimic that of the parent compound.Key words: tamoxifen, radioimaging, technetium, synthesis.
Authors
Bell RA; Dickson KC; Valliant JF
Journal
Canadian Journal of Chemistry, Vol. 77, No. 1, pp. 146–154
Publisher
Canadian Science Publishing
Publication Date
January 1, 1999
DOI
10.1139/v98-220
ISSN
0008-4042