Reductions in RIP140 are not required for exercise and high fat diet mediated increases in mitochondrial enzymes

The over‐expression of RIP140 reduces the expression of mitochondrial enzymes whereas the deletion of RIP140 increases mitochondrial content. Despite the importance of RIP140 in the control of mitochondrial biogenesis the effects of physiological perturbations on regulating RIP140 in skeletal muscle has not been determined. To this end, rats were exercised by 2 hours of daily swim training for 14 consecutive days or fed a high fat diet (HFD) …