Multifaceted Intervention to Increase the Use of Home Dialysis Journal Articles uri icon

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  • Background and objectives Home dialysis therapies (peritoneal and home hemodialysis) are less expensive and provide similar outcomes to in-center hemodialysis, but they are underutilized in most health systems. Given this, we designed a multifaceted intervention to increase the use of home dialysis. In this study, our objective was to evaluate the effect of this intervention on home dialysis use in CKD clinics across Canada. Design, setting, participants, & measurements We conducted a cluster randomized controlled trial in 55 CKD clinic clusters in nine provinces in Canada between October 2014 and November 2015. Participants included all adult patients who initiated dialysis in the year following the intervention. We evaluated the implementation of a four-component intervention, which included phone surveys from a knowledge translation broker, a 1-year center-specific audit/feedback on home dialysis use, delivery of an educational package (including tools aimed at both providers and patients), and an academic detailing visit. The primary outcome was the proportion of patients using home dialysis at 180 days after dialysis initiation. Results A total of 55 clinics were randomized (27 in the intervention and 28 in the control), with 5312 patients initiating dialysis in the 1-year follow-up period. In the primary analysis, there was no difference in the use of home dialysis at 180 days in the intervention and control clusters (absolute risk difference, 4%; 95% confidence interval, −2% to 10%). Using a difference-in-difference comparison, the use of home dialysis at 180 days was similar before and after implementation of the intervention (difference of 0% in intervention clinics; 95% confidence interval, −2% to 3%; difference of 0.8% in control clinics; 95% confidence interval, −1% to 3%; P=0.84). Conclusions A multifaceted intervention did not increase the use of home dialysis in adults initiating dialysis. Clinical Trial registry name and registration number: A Cluster Randomized Trial to Assess the Impact of Patient and Provider Education on Use of Home Dialysis, NCT02202018


  • Manns, Braden J
  • Garg, Amit
  • Sood, Manish M
  • Ferguson, Thomas
  • Kim, S Joseph
  • Naimark, David
  • Nesrallah, Gihad E
  • Soroka, Steven D
  • Beaulieu, Monica
  • Dixon, Stephanie N
  • Alam, Ahsan
  • Allu, Selina
  • Tangri, Navdeep

publication date

  • April 2022