Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein Journal Articles

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abstract

Stable protein complexes between the large T antigens of mouse, monkey, baboon, or human polyomaviruses and the retinoblastoma protein were detected by an in vitro coimmunoprecipitation assay. All of the large T antigens tested were able to bind to both human and mouse retinoblastoma polypeptides, showing that these interactions have been conserved during evolution.

authors

Dyson, N
Bernards, R
Friend, SH
Gooding, LR
Hassell, John Algernon
Major, EO
Pipas, JM
Vandyke, T
Harlow, E

status

published

publication date

March 1990

has subject area

06 Biological Sciences (FoR)
07 Agricultural and Veterinary Sciences (FoR)
11 Medical and Health Sciences (FoR)
Amino Acid Sequence (MeSH)
Animals (MeSH)
Antigens, Polyomavirus Transforming (MeSH)
Haplorhini (MeSH)
Humans (MeSH)
Molecular Sequence Data (MeSH)
Nuclear Proteins (MeSH)
Papio (MeSH)
Phosphoproteins (MeSH)
Polyomavirus (MeSH)
Protein Binding (MeSH)
Retinoblastoma Protein (MeSH)
Sequence Homology, Nucleic Acid (MeSH)
Virology (Science Metrix)

published in

Journal of Virology Journal