Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. Academic Article uri icon

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abstract

  • Stable protein complexes between the large T antigens of mouse, monkey, baboon, or human polyomaviruses and the retinoblastoma protein were detected by an in vitro coimmunoprecipitation assay. All of the large T antigens tested were able to bind to both human and mouse retinoblastoma polypeptides, showing that these interactions have been conserved during evolution.

authors

publication date

  • March 1990