Activation of the CRF 2 receptor modulates skeletal muscle mass under physiological and pathological conditions Journal Articles uri icon

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  • Two receptors activated by the corticotropin-releasing factor (CRF) family of peptides have been identified, the CRF 1 receptor (CRF1R) and the CRF 2 receptor (CRF2R). Of these, the CRF2R is expressed in skeletal muscle. To understand the role of the CRF2R in skeletal muscle, we utilized CRFR knockout mice and CRF2R-selective agonists to modulate nerve damage and corticosteroid- and disuse-induced skeletal muscle atrophy in mice. These analyses demonstrated that activation of the CRF2R decreased nerve damage and corticosteroid- and disuse-induced skeletal muscle mass and function loss. In addition, selective activation of the CRF2R increased nonatrophy skeletal muscle mass. Thus we describe for the first time a novel activity of the CRF2R, modulation of skeletal muscle mass.


  • Hinkle, Richard T
  • Donnelly, Elizabeth
  • Cody, David B
  • Samuelsson, Steven
  • Lange, Jana S
  • Bauer, Mary Beth
  • Tarnopolsky, Mark
  • Sheldon, Russell J
  • Coste, Sarah C
  • Tobar, Eric
  • Stenzel-Poore, Mary P
  • Isfort, Robert J

publication date

  • October 2003

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