Journal article
Sensitization and tolerance to apomorphine in men: Yawning, growth hormone, nausea, and hyperthermia
Abstract
This study investigated whether the indices of dopaminergic function, yawning and growth hormone release induced by apomorphine, as well as the drug-induced nausea and hyperthermia, show sensitization or tolerance to repeated injections. Five normal volunteers received 12 injections of apomorphine hydrochloride (0.75 mg/70 kg) every 2 weeks. Yawning, as measured by the latency of onset and the time of peak activity, showed sensitization. The …
Authors
Szechtman H; Cleghorn JM; Brown GM; Kaplan RD; Franco S; Rosenthal K
Journal
Psychiatry Research, Vol. 23, No. 3, pp. 245–255
Publisher
Elsevier
Publication Date
3 1988
DOI
10.1016/0165-1781(88)90015-7
ISSN
0165-1781