Journal article
Review: Behaviour of MRL Mice: An Animal Model of Disturbed Behaviour in Systemic Autoimmune Disease
Abstract
Evidence is reviewed indicating that development of lupus-like disease in the MRL-lpr substrain of mice coincides with a change in behaviour, suggestive of altered emotional reactivity and cognitive performance. The altered behaviour, termed 'autoimmunity-associated behavioural syndrome', is related to abnormal autoantibody and cytokine production. Moreover, immunosuppressive treatment with cyclophosphamide prevents the appearance of some …
Authors
Szechtman H; Šakić B; Denburg JA
Journal
Lupus, Vol. 6, No. 3, pp. 223–229
Publisher
SAGE Publications
Publication Date
March 1997
DOI
10.1177/096120339700600302
ISSN
0961-2033