Journal article
Antidepressants Attenuate Increased Susceptibility to Colitis in a Murine Model of Depression
Abstract
BACKGROUND & AIMS: Psychiatric factors may determine gastrointestinal health outcomes. Here, we used a model of depression based on neonatal maternal separation (MS) to identify alterations in gut physiology and to assess its association with increased sensitivity to experimental colitis in adulthood. We also examined whether antidepressant therapy attenuates the increased susceptibility to colitis.
METHODS: C57BL/6 mouse pups were separated …
Authors
Varghese AK; Verdú EF; Bercik P; Khan WI; Blennerhassett PA; Szechtman H; Collins SM
Journal
Gastroenterology, Vol. 130, No. 6, pp. 1743–1753
Publisher
Elsevier
Publication Date
May 2006
DOI
10.1053/j.gastro.2006.02.007
ISSN
0016-5085
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
AnimalsAnimals, NewbornAntidepressive AgentsColitisCytokinesDepressionDisease Models, AnimalDisease SusceptibilityDose-Response Relationship, DrugDrug Administration ScheduleFemaleGastrointestinal MotilityInflammation MediatorsMiceMice, Inbred C57BLProbabilityRandom AllocationReference ValuesRisk FactorsSensitivity and Specificity