Journal article
Differential effects of clorgyline on sensitization to quinpirole in rats tested in small and large environments
Abstract
RationaleCotreatment with clorgyline shifts the development of sensitization to the D2/D3 dopamine receptor agonist quinpirole from locomotion to mouthing, an effect apparently unrelated to the monoamine oxidase inhibition property of clorgyline. This phenomenon was demonstrated in rats examined in small activity chambers. However, like with other psychostimulant drugs, sensitization to quinpirole is modulated by environmental context. It is …
Authors
Dvorkin A; Culver KE; Szechtman H
Journal
Psychopharmacology, Vol. 186, No. 4, pp. 534–543
Publisher
Springer Nature
Publication Date
July 2006
DOI
10.1007/s00213-006-0377-4
ISSN
0033-3158