Journal article
Advanced chronic kidney disease populations have elevated trimethylamine N-oxide levels associated with increased cardiovascular events
Abstract
Cardiovascular disease is more common in patients with chronic kidney disease (CKD), and traditional risk factors do not adequately predict those at risk for cardiovascular (CV) events. Recent evidence suggests elevated trimethylamine N-oxide (TMAO), created by gut microflora from dietary L-carnitine and choline, is associated with CV events. We investigated the relationship of TMAO levels in patients with stages 3b and 4 CKD to ischemic CV …
Authors
Kim RB; Morse BL; Djurdjev O; Tang M; Muirhead N; Barrett B; Holmes DT; Madore F; Clase CM; Rigatto C
Journal
Kidney International, Vol. 89, No. 5, pp. 1144–1152
Publisher
Elsevier
Publication Date
May 2016
DOI
10.1016/j.kint.2016.01.014
ISSN
0085-2538
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
AgedAged, 80 and overBiomarkersCanadaCardiovascular DiseasesDisease-Free SurvivalFemaleGlomerular Filtration RateHumansKaplan-Meier EstimateKidneyMaleMethylaminesMiddle AgedProspective StudiesRenal Insufficiency, ChronicRisk AssessmentRisk FactorsSeverity of Illness IndexTandem Mass SpectrometryTime FactorsUp-Regulation