Journal article
Randomized trial to examine the effect of ASA dose or ASA dosing frequency on ASA resistance after coronary artery bypass graft surgery
Abstract
Purpose: Low-dose ASA (81 mg daily) is administered after coronary artery bypass graft (CABG) surgery to reduce the risk of graft failure. There is transient ASA resistance after such surgery, which may compromise its effectiveness. Because such resistance may reflect the failure of once-daily, low-dose ASA to acetylate cyclo-oxygenase (COX)-1 and inhibit thomboxane A2 (TXA2) synthesis in the setting of the increased platelet turnover that …
Authors
Paikin JS; Eikelboom JW; Whitlock RP; Ginsberg JS; Weitz JI; Pare G; Hirsh J
Journal
European Heart Journal, Vol. 34, No. suppl_1,
Publisher
Oxford University Press (OUP)
Publication Date
August 2, 2013
DOI
10.1093/eurheartj/eht307.p234
ISSN
0195-668X