Estrogen Metabolism and Prostate Cancer Risk

Prostate cancer is the most common non-skin cancer among men in industrialized countries (I). The causes of prostate cancer, however, remain largely unknown, with age, race, and family history being the only established risk factors (2). The prostate gland has historically been considered the prototype of an androgen-dependent organ. However, there is evidence that estrogens may induce mitosis of both normal and malignant prostatic epithelial …