Skeletal Muscle Regeneration Impairment in Type 1 Diabetes Mellitus is Characterized by Dysregulated Sphingosine‐1‐Phosphate and Ceramide‐1‐Phosphate Responses

Type 1 diabetes mellitus (T1DM) impairs regenerative capacity of skeletal muscle, one of several aspects of diabetic myopathy. It was hypothesized that accumulation of lipid species within the muscle (lipotoxicity) could cause this impairment. Although it has been demonstrated that diabetes causes increased lipid deposition in skeletal muscle, the muscle lipid response following tissue damage has not been investigated. To assess the effect of …