Completed suicide is among the leading causes of death worldwide. Globally, it accounts for more annual deaths than natural disasters, violence inflicted by others, war, and conflict combined. High occupational completed suicide rates are often linked to factors such as easy access to a method of suicide, social isolation at work, the natural selection of high-risk people to certain occupations, and socioeconomic forces. Physicians and other healthcare workers are considered a high-risk suicide group, and suicide risk seems to be higher for male and female physicians than the general population. Beyond that, the suicide risk appears to be present throughout the entire medical career. The aim of this chapter is to review the epidemiology of suicidality in physicians, risk factors related to suicidal behavior in physicians, suicide risk assessment, and suicide prevention.