Journal article
Induction of Oxidative Stress in SH-SY5Y Cells by Overexpression of hTau40 and Its Mitigation by Redox-Active Nanoparticles
Abstract
Abnormally phosphorylated tau protein is the principal component of neurofibrillary tangles, accumulating in the brain in many neurodegenerative diseases, including Alzheimer's disease. The aim of this study was to examine whether overexpression of tau protein leads to changes in the redox status of human neuroblastoma SH-SY5Y cells. The level of reactive oxygen species (ROS) was elevated in tau-overexpressing cells (TAU cells) as compared with …
Authors
Pieńkowska N; Fahnestock M; Mahadeo C; Zaborniak I; Chmielarz P; Bartosz G; Sadowska-Bartosz I
Journal
International Journal of Molecular Sciences, Vol. 24, No. 1,
Publisher
MDPI
DOI
10.3390/ijms24010359
ISSN
1661-6596