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Common variants at the MHC locus and at chromosome...
Journal article

Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus

Abstract

Peter Donnelly and colleagues report a genome-wide association study for Barrett's esophagus, a common premalignant condition associated with stomach acid reflux and predisposing to esophageal adenocarcinoma. They identify two loci associated with susceptibility to Barrett's esophagus.

Authors

Su Z; Gay LJ; Strange A; Palles C; Band G; Whiteman DC; Lescai F; Langford C; Nanji M; Edkins S

Journal

Nature Genetics, Vol. 44, No. 10, pp. 1131–1136

Publisher

Springer Nature

Publication Date

January 1, 2012

DOI

10.1038/ng.2408

ISSN

1061-4036

Associated Experts

Paul Moayyedi

Professor, Faculty of Health Sciences
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Labels

Fields of Research (FoR)

31 Biological Sciences3105 Genetics3001 Agricultural biotechnology3102 Bioinformatics and computational biology

Medical Subject Headings (MeSH)

AdultAgedBarrett EsophagusCase-Control StudiesChromosomes, Human, Pair 16FemaleGene FrequencyGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLinkage DisequilibriumMajor Histocompatibility ComplexMaleMiddle AgedModels, GeneticPolymorphism, Single Nucleotide
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