Journal article
Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection
Abstract
Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2 infection and have been suggested to be a useful correlate of protection for vaccine clinical trials and for population-level surveys. In addition to neutralizing virus directly, antibodies can also engage immune effectors through their Fc domains, including Fc receptor-expressing immune cells and complement. The outcome of these interactions depends on a …
Authors
Zhang A; Stacey HD; D’Agostino MR; Tugg Y; Marzok A; Miller MS
Journal
Nature Reviews Immunology, Vol. 23, No. 6, pp. 381–396
Publisher
Springer Nature
Publication Date
June 2023
DOI
10.1038/s41577-022-00813-1
ISSN
1474-1733