Modeling the effect of HIV coinfection on clearance and sustained virologic response during treatment for hepatitis C virus

BACKGROUND: HIV/hepatitis C (HCV) coinfection is a major concern in global health today. Each pathogen can exacerbate the effects of the other and affect treatment outcomes. Understanding the within-host dynamics of these coinfecting pathogens is crucial, particularly in light of new, direct-acting antiviral agents (DAAs) for HCV treatment that are becoming available. METHODS AND FINDINGS: In this study, we construct a within-host mathematical …