Journal article
Myoadenylate deaminase deficiency does not affect muscle anaplerosis during exhaustive exercise in humans
Abstract
1. Myoadenylate deaminase (AMPD) deficiency is present in 1--2 % of the population. In theory, this deficiency may alter exercise energy metabolism by impairing the purine nucleotide cycle (PNC) and reducing tricarboxylic acid (TCA) cycle anaplerosis. The role of the PNC in TCA cycle anaplerosis is still a debated issue in physiology. Using patients with the AMPD1 mutation will allow a human 'knockout' approach to answering this question. 2. …
Authors
Tarnopolsky MA; Parise G; Gibala MJ; Graham TE; Rush JWE
Journal
The Journal of Physiology, Vol. 533, No. 3, pp. 881–889
Publisher
Wiley
Publication Date
June 2001
DOI
10.1111/j.1469-7793.2001.t01-1-00881.x
ISSN
0022-3751