Journal article
Robust and High-Throughput Method for Anionic Metabolite Profiling: Preventing Polyimide Aminolysis and Capillary Breakages under Alkaline Conditions in Capillary Electrophoresis-Mass Spectrometry
Abstract
Capillary electrophoresis-mass spectrometry (CE-MS) represents a high efficiency microscale separation platform for untargeted profiling of polar/ionic metabolites that is ideal for volume-restricted biological specimens with minimal sample workup. Despite these advantages, the long-term stability of CE-MS remains a major obstacle hampering its widespread application in metabolomics notably for routine analysis of anionic metabolites under …
Authors
Yamamoto M; Ly R; Gill B; Zhu Y; Moran-Mirabal J; Britz-McKibbin P
Journal
Analytical Chemistry, Vol. 88, No. 21, pp. 10710–10719
Publisher
American Chemical Society (ACS)
Publication Date
November 1, 2016
DOI
10.1021/acs.analchem.6b03269
ISSN
0003-2700