Amine‐ and Sulfonamide‐Promoted Wittig Olefination Reactions in Water Journal Articles uri icon

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abstract

  • Amine-promoted olefination: The reaction of a phosphonium salt and an aldehyde in water to yield alkenes with high E-configurational control is promoted by catalytic amounts of non-basic amines in aqueous bicarbonate media. Possible catalytic cycles involving imines and iminium intermediates are discussed.

publication date

  • August 2011