Journal article
Total synthesis of the cyanobacterial metabolite nostodione A: discovery of its antiparasitic activity against Toxoplasma gondii
Abstract
A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route. A small assemblage of structural analogues were prepared and their cytotoxicity and anti-invasion activity against the protozoal parasite Toxoplasma gondii is reported for the first time.
Authors
McNulty J; Keskar K; Bordón C; Yolken R; Jones-Brando L
Journal
Chemical Communications, Vol. 50, No. 64, pp. 8904–8907
Publisher
Royal Society of Chemistry (RSC)
Publication Date
August 18, 2014
DOI
10.1039/c4cc03904a
ISSN
1359-7345