Phosphaadamantanes as Ligands for Palladium Catalyzed Cross-Coupling Chemistry:  Library Synthesis, Characterization, and Screening in the Suzuki Coupling of Alkyl Halides and Tosylates Containing β-Hydrogens with Boronic Acids and Alkylboranes Academic Article uri icon

  • Overview
  • Identity
  • Additional Document Info
  • View All


  • A 15-member library of phosphaadamantane ligands has been prepared via P-arylation of 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phosphaadamantane. Screening of this tertiary phosphine collection has allowed for the rapid determination of the most suitable ligand, specifically 1,3,5,7-tetramethyl-6-(2,4-dimethoxyphenyl)-2,4,8-trioxa-6-phosphaadamantane, for facilitating Suzuki-type couplings of alkyl halides or tosylates containing beta-hydrogens with either boronic acids or alkylboranes.


  • Brenstrum, Tim
  • Gerristma, David A
  • Adjabeng, George M
  • Frampton, Christopher S
  • Britten, James
  • Robertson, Alan J
  • McNulty, James
  • Capretta, Alfredo

publication date

  • October 2004