Phosphorinanes as Ligands for Palladium-Catalyzed Cross-Coupling Chemistry Academic Article uri icon

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abstract

  • [structure: see text] Phosphorinanes are presented as a class of phosphine ligand suitable for organopalladium cross-coupling chemistry. Prepared via a direct double Michael addition of a monoalkyl- or arylphosphine to phorone followed by a Wolf-Kishner reduction, phosphorinanes are relatively inexpensive to manufacture and allow modification of one of the alkyl moieties permitting steric and electronic fine-tuning of the ligands. Library screening and applications of these ligands in the Suzuki, Sonogashira, ketone arylation, and aryl amination reactions are presented.

authors

  • Brenstrum, Tim
  • Clattenburg, Julie
  • Britten, James
  • Zavorine, Serguei
  • Dyck, Jeff
  • Robertson, Alan J
  • McNulty, James
  • Capretta, Alfredo

publication date

  • January 2006