Journal article
Placebo Response Rates in Randomized Controlled Trials for Perianal Crohn's Disease: A Systematic Review and Meta-Analysis.
Abstract
BACKGROUND AND AIMS: Perianal fistulizing disease is a common complication of Crohn's disease [CD], for which new therapies are urgently needed. To assist the design of clinical trials for novel therapeutics, we conducted a systematic review and meta-analysis of randomised controlled trials [RCTs] to quantify placebo rates and identify factors influencing them in perianal CD [pCD].
METHODS: We searched MEDLINE, Embase and CENTRAL from inception …
Authors
Sharma T; Ma C; Sedano R; Hanzel J; McDonald C; Hogan M; Kochhar GS; Narula N; Peyrin-Biroulet L; Danese S
Journal
Journal of Crohn's and Colitis, Vol. 17, No. 4, pp. 644–658
Publisher
Oxford University Press (OUP)
Publication Date
April 19, 2023
DOI
10.1093/ecco-jcc/jjac160
ISSN
1197-4982