Journal article
The synthesis, magnetic purification and evaluation of 99mTc-labeled microbubbles
Abstract
INTRODUCTION: Ultrasound (US) contrast agents based on microbubbles (MBs) are being investigated as platforms for drug and gene delivery. A methodology for determining the distribution and fate of modified MBs quantitatively in vivo can be achieved by tagging MBs directly with (99m)Tc. This creates the opportunity to employ dual-modality imaging using both US and small animal SPECT along with quantitative ex vivo tissue counting to evaluate …
Authors
Lazarova N; Causey PW; Lemon JA; Czorny SK; Forbes JR; Zlitni A; Genady A; Foster FS; Valliant JF
Journal
Nuclear Medicine and Biology, Vol. 38, No. 8, pp. 1111–1118
Publisher
Elsevier
Publication Date
11 2011
DOI
10.1016/j.nucmedbio.2011.04.008
ISSN
0969-8051