Adverse Pregnancy Outcomes in Sickle Cell Disease With Abnormal Placental Weight to Birthweight Ratios [27C]
Conferences
Overview
Research
Identity
Additional Document Info
View All
Overview
abstract
INTRODUCTION:Low placental weight to birthweight (PW:BW) ratio is a marker of abnormal placental development, and is linked with perinatal morbidity and mortality. Sickle cell disease (SCD), the most common hemoglobinopathy worldwide, is associated with placentally-mediated complications; yet, PW:BW ratios in this context have not been studied. Our aim was to investigate PW:BW ratios in pregnancies of women with SCD, and its association with adverse pregnancy outcomes.METHODS:Research ethics board approval was obtained, and records of women with SCD were retrospectively reviewed between January 1, 2000 to December 31, 2017 at our institution. For twin pregnancies, neonatal data for a randomly chosen single twin was included. Significance was set at P<.05.RESULTS:Seventy-one pregnancies in 66 women, including 3 twin pregnancies, were analyzed. Low PW:BW ratio (<10th centile) is associated with male fetal sex [22/40 with low ratio (55%) vs 7/31 with normal ratio (23%), P=.006] and preterm birth [20/40 with low ratio (50%) vs 7/31 with normal ratio (23%), P=.018]. There was no association of low PW:BW with small-for-gestational-age infants [8/40 with low ratio (20%) vs 10/31 with normal ratio (32%), P=.239], stillbirth [3/40 with low ratio (8%) vs 1/31 with normal ratio (3%), P=.627], or maternal hypertensive disorders of pregnancy [5/40 with low ratio (13%) vs 7/31 with normal ratio (23%), P=.261].CONCLUSION:Low PW:BW ratio is more prevalent in male fetuses, and associated with preterm birth. The lack of association with other adverse pregnancy outcomes may be based on histologic placental adaptation. Further investigation is necessary to elucidate contributing factors.
