Journal article
Single-cell spatial proteomic imaging for human neuropathology
Abstract
Neurodegenerative disorders are characterized by phenotypic changes and hallmark proteopathies. Quantifying these in archival human brain tissues remains indispensable for validating animal models and understanding disease mechanisms. We present a framework for nanometer-scale, spatial proteomics with multiplex ion beam imaging (MIBI) for capturing neuropathological features. MIBI facilitated simultaneous, quantitative imaging of 36 proteins on …
Authors
Vijayaragavan K; Cannon BJ; Tebaykin D; Bossé M; Baranski A; Oliveria JP; Bukhari SA; Mrdjen D; Corces MR; McCaffrey EF
Journal
Acta Neuropathologica Communications, Vol. 10, No. 1,
Publisher
Springer Nature
DOI
10.1186/s40478-022-01465-x
ISSN
2051-5960