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Transformation of rat cells by DNA of human...
Journal article

Transformation of rat cells by DNA of human adenovirus 5

Abstract

Primary rat embryo and baby rat kidney cells have been transformed by human adenovirus 5 DNA. Transforming activity was resistant to heating (1 hr at 56 °C), and to pronase, but was sensitive to DNase. The efficiency of transformation was approximately 1 transformed focus/μg DNA.

Authors

Graham FL; Van Der Eb AJ

Journal

Virology, Vol. 54, No. 2, pp. 536–539

Publisher

Elsevier

Publication Date

January 1, 1973

DOI

10.1016/0042-6822(73)90163-3

ISSN

0042-6822

Associated Experts

Frank Lawson Graham

Professor Emeritus, Faculty of Science
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Labels

Fields of Research (FoR)

3215 Reproductive Medicine32 Biomedical and clinical sciences30 Agricultural, veterinary and food sciences31 Biological sciences

Medical Subject Headings (MeSH)

AdenoviridaeAnimalsAntigens, NeoplasmCalcium ChlorideCell Transformation, NeoplasticCells, CulturedComplement Fixation TestsDNA, ViralDeoxyribonucleasesDose-Response Relationship, DrugGenetic Complementation TestHot TemperatureHumansKidneyPronaseRatsTime Factors
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