Journal article
Expression of the adenovirus E1A oncogene during cell transformation is sufficient to induce susceptibility to lysis by host inflammatory cells.
Abstract
Mammalian cells transformed by nononcogenic human adenoviruses exhibit high susceptibility to destruction by host mononuclear inflammatory cells. We have analyzed the viral gene regulation of the susceptibility of transformed cells to lysis by natural killer cells and activated macrophages. Comparisons of target cell lines transformed by overlapping segments of the adenovirus E1-transforming gene region revealed that isolated expression of a …
Authors
Cook JL; Walker TA; Lewis AM; Ruley HE; Graham FL; Pilder SH
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, No. 18, pp. 6965–6969
Publisher
Proceedings of the National Academy of Sciences
Publication Date
9 1986
DOI
10.1073/pnas.83.18.6965
ISSN
0027-8424