Journal article
Recombinant Truncated Dystrophin Minigenes: Construction, Expression, and Adenoviral Delivery
Abstract
Duchenne muscular dystrophy (DMD) is a lethal genetic disorder for which there is currently no effective treatment. Although clinical application of adenoviral vector-mediated gene transfer has not been fully developed, it shows promise for the treatment of DMD. One significant problem posed by adenoviral vector-mediated gene transfer for DMD is that currently available adenoviral vectors cannot accommodate the entire 14-kb dystrophin cDNA. To …
Authors
Clemens PR; Krause TL; Chan S; Korb KE; Graham FL; Caskey CT
Journal
Human Gene Therapy, Vol. 6, No. 11, pp. 1477–1485
Publisher
Mary Ann Liebert
Publication Date
11 1995
DOI
10.1089/hum.1995.6.11-1477
ISSN
1043-0342