Journal article
A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal
Abstract
Adenoviruses are attractive vectors for the delivery of foreign genes into mammalian cells for gene therapy. However, current vectors retain many viral genes that, when expressed at low levels, contribute to the induction of a host immune response against transduced cells. We have developed a helper-dependent packaging system for production of vectors that have large regions of the genome deleted. Helper viruses were constructed with packaging …
Authors
Parks RJ; Chen L; Anton M; Sankar U; Rudnicki MA; Graham FL
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, No. 24, pp. 13565–13570
Publisher
Proceedings of the National Academy of Sciences
Publication Date
November 26, 1996
DOI
10.1073/pnas.93.24.13565
ISSN
0027-8424