Data Driven Modeling and Model Predictive Control of Bioreactor for Production of Monoclonal Antibodies

This manuscript focuses on data driven modeling and control of an industrial bioreactor used by Sartorius to grow cells to produce monoclonal antibodies, demonstrated using a high fidelity simulation test bed. The contribution of this paper is the development of a subspace model based model predictive controller (MPC) for the bioreactor with constraints in place to manage the delicate cell health and growth. Subspace identification is first …