Incidence and Risk Factors for Severe Preeclampsia, Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome, and Eclampsia at Preterm and Term Gestation: A Population-based Study

( Am J Obstet Gynecol . 2021;225:538.e1–538.e19) Preeclampsia is a complication of pregnancy that is among the most common in high-income countries and portents other sequelae including severe preeclampsia, eclampsia, and HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count syndrome). Prevalence of these serious diagnoses range from 0.2 to 7.6 per 1000 deliveries in high-income countries. The risk factors and gestational age-specific incidence of preeclampsia with severe features, eclampsia and HELLP syndrome is not well characterized, and previous investigations of these outcomes have been hospital-based with small numbers of patients. This study provides a large population-based inquiry into the development of these further related conditions following preeclampsia at term and preterm gestation, along with associations of maternal and clinical factors.