Journal article
Vascular burden and cognition: Mediating roles of neurodegeneration and amyloid PET
Abstract
It remains unclear to what extent cerebrovascular burden relates to amyloid beta (Aβ) deposition, neurodegeneration, and cognitive dysfunction in mixed disease populations with small vessel disease and Alzheimer's disease (AD) pathology. In 120 subjects, we investigated the association of vascular burden (white matter hyperintensity [WMH] volumes) with cognition. Using mediation analyses, we tested the indirect effects of WMH on cognition via …
Authors
Ottoy J; Ozzoude M; Zukotynski K; Adamo S; Scott C; Gaudet V; Ramirez J; Swardfager W; Cogo‐Moreira H; Lam B
Journal
Alzheimer's & Dementia, Vol. 19, No. 4, pp. 1503–1517
Publisher
Wiley
Publication Date
4 2023
DOI
10.1002/alz.12750
ISSN
1552-5260